TOPBP1

Across TCGA patient cohorts, TOPBP1 protein abundance is significantly associated with the protein abundance of many other proteins, with 27,853 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TOPBP1-associated proteins across cancer lineages are RRM2, ATAD2, and SPC24. Each is linked with TOPBP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TOPBP1-to-partner and partner-to-TOPBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOPBP1 versus RRM2 in UCEC, with a Pearson correlation of 0.77.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPBP1→partner) and Y-score (partner→TOPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RRM2 →	+0.925	+0.423	<.001	<.001	3	8
LSCC	ATAD2 →	+0.675	+0.495	<.001	<.001	3	8
GBM	SPC24 →	+0.708	+0.486	<.001	<.001	3	8
LUAD	AURKB →	+0.934	+0.258	<.001	<.001	3	8
UCEC	CCNB1 →	+0.869	+0.369	<.001	<.001	3	8
OV	KIF20A →	+0.660	+0.432	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 27,853 associations by consensus.

TOPBP1 vs RRM2 — UCEC

Explore this scatter interactively →