TOPBP1

Across TCGA patient cohorts, TOPBP1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,183 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TOPBP1-associated genes across cancer lineages are PIF1, MKI67, and MCM5. Each is linked with TOPBP1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TOPBP1-to-partner and partner-to-TOPBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOPBP1 versus PIF1 in UCEC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPBP1→partner) and Y-score (partner→TOPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIF1 →	+0.861	+0.275	<.001	<.001	3	8
UCEC	MKI67 →	+1.156	+0.402	<.001	<.001	3	8
UCEC	MCM5 →	+1.176	+0.379	<.001	<.001	3	7
LSCC	POLE2 →	+0.962	+0.587	<.001	<.001	3	7
LUAD	MYBL2 →	+1.639	+0.366	<.001	<.001	3	7
UCEC	E2F1 →	+1.192	+0.310	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,183 associations by consensus.

TOPBP1 vs PIF1 — UCEC

Explore this scatter interactively →