TOPBP1

Across TCGA patient cohorts, TOPBP1 RNA expression is significantly associated with the RNA expression of many other genes, with 20,390 significant associations in total. ACC shows the largest number of these associations.

The most reproducible TOPBP1-associated genes across cancer lineages are RYK, WDR43, and ZNF148. Each is linked with TOPBP1 in more than 33 cancer types. Because this analysis shows association rather than direction, both TOPBP1-to-partner and partner-to-TOPBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOPBP1 versus RYK in UVM, with a Pearson correlation of 0.95.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPBP1→partner) and Y-score (partner→TOPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	RYK →	+1.349	+1.389	<.001	<.001	3	34
UVM	WDR43 →	+1.656	+1.304	<.001	<.001	3	34
UVM	ZNF148 →	+1.448	+1.453	<.001	<.001	3	34
UVM	YEATS2 →	+1.141	+1.375	<.001	<.001	3	34
KICH	SENP2 →	+1.194	+1.257	<.001	<.001	3	34
UVM	SLBP →	+1.065	+1.259	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,390 associations by consensus.

TOPBP1 vs RYK — UVM

Explore this scatter interactively →