TOPBP1

Across TCGA patient cohorts, TOPBP1 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,378 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TOPBP1-associated proteins across cancer lineages are SMC2, SMC4, and MCM3. Each is linked with TOPBP1 in more than 9 cancer types. Because this analysis shows association rather than direction, both TOPBP1-to-partner and partner-to-TOPBP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TOPBP1 versus SMC2 in GBM, with a Pearson correlation of 0.78.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPBP1→partner) and Y-score (partner→TOPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.649	+0.439	<.001	<.001	3	10
GBM	SMC4 →	+0.612	+0.453	<.001	<.001	3	10
LUAD	MCM3 →	+0.816	+0.601	<.001	<.001	3	10
LUAD	MCM4 →	+0.842	+0.615	<.001	<.001	3	10
LUAD	MCM5 →	+0.791	+0.615	<.001	<.001	3	10
BRCA	MCM6 →	+0.838	+0.544	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,378 associations by consensus.

TOPBP1 vs SMC2 — GBM

Explore this scatter interactively →