Q-omics provides the consensus-scored SMC4 profile across patient tissues and cancer cell-line models. SMC4 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, SMC4 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, SMC4 protein abundance shows 34,596 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight MESO, HNSC, and LSCC as cancer lineages where SMC4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SMC4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SMC4 survival associations across molecular data types. SMC4 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (7) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SMC4 RNA expression–survival associations across cancer types. High SMC4 expression shows unfavorable associations in MESO, ACC, KICH, KIRP, PAAD and LGG. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for SMC4 RNA expression.
This table summarizes SMC4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 8. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SMC4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SMC4 shows higher tumor expression in HNSC, BLCA, KIRC, LUSC, STAD and LIHC. The HNSC box plot shows higher SMC4 RNA expression in tumor versus normal tissue (log2 FC = +1.671, t-test p < 0.001).
This table shows molecular features associated with SMC4 in patient tissues and cancer cell lines. In patient samples, SMC4 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SMC4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in CNS and BLOOD_Leukemia.
