SMC4

Across TCGA cell cohorts, SMC4 mutation is significantly associated with the RNA expression of many other genes, with 306 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SMC4-associated genes across cancer lineages are DNAJC5B, RNASE8, and ZNRF4. Each is linked with SMC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SMC4-to-partner and partner-to-SMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC5B grouped by SMC4-low versus SMC4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC4→partner) and Y-score (partner→SMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DNAJC5B →	+0.298	+4.321	<.001	.001	3	2
URINARY_TRACT	RNASE8 →	+0.036	+3.584	<.001	.005	3	2
KIDNEY	ZNRF4 →	+0.013	+5.000	<.001	.005	3	2
PANCREAS	FAM240A →	+0.010	+4.614	<.001	.004	3	2
LUNG_NSCLC_LUAD	SPINK7 →	+1.127	+2.740	.001	.009	3	2
LARGE_INTESTINE	FGF8 →	+0.276	+2.619	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 306 associations by consensus.

DNAJC5B by SMC4 expression — URINARY_TRACT

Explore this box plot interactively →