SMC4

Across TCGA pan-cancer cohorts, SMC4 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SMC4 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher SMC4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SMC4 expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

MESO, ACC, and KICH are the cancer types where SMC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	III,IV	0.439	0.680	<.001	126	view →
ACC	DFS	Median	All	0.392	0.771	<.001	96	view →
KICH	OS	Median	All	0.748	1.000	.001	85	view →
KIRP	DFS	Tertile	All	0.746	0.920	<.001	85	view →
PAAD	OS	Tertile	All	0.209	0.551	<.001	64	view →
LGG	OS	Median	All	0.715	0.914	<.001	54	view →
UCEC	DFS	Tertile	All	0.792	0.898	.001	48	view →
LIHC	DFS	Quartile	All	0.431	0.641	<.001	44	view →
SARC	DFS	Tertile	All	0.494	0.692	<.001	29	view →
KIRC	DFS	Quartile	IV	0.258	0.605	.003	28	view →
UVM	DFS	Quartile	III,IV	0.183	0.825	.001	26	view →
UCS	OS	Tertile	II,III,IV	0.571	0.204	.004	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SMC4–MESO (OS)

Open the MESO breakdown →