SMC4

Across TCGA cell cohorts, SMC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,665 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SMC4-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Microtubule cytoskeleton organization involved in mitosis, and Chromosome segregation. Each is linked with SMC4 in more than 19 cancer types. Because this analysis shows association rather than direction, both SMC4-to-partner and partner-to-SMC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by SMC4-low versus SMC4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SMC4→partner) and Y-score (partner→SMC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.069	+1.434	<.001	<.001	3	20
SKIN	Microtubule cytoskeleton organization involved in mitosis →	+0.120	+1.343	<.001	<.001	3	20
OESOPHAGUS	Chromosome segregation →	+0.119	+1.306	.001	.001	3	20
BREAST	Mitotic chromosome condensation →	+0.188	+1.321	<.001	<.001	3	20
SOFT_TISSUE	Regulation of chromosome condensation →	+0.201	+1.073	<.001	<.001	3	20
PANCREAS	Spindle elongation →	+0.232	+0.953	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,665 associations by consensus.

Negative regulation of cell cycle process by SMC4 expression — BLOOD_Myeloma

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