TOPBP1

Across TCGA cell cohorts, TOPBP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,943 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TOPBP1-associated GO terms across cancer lineages are Mitotic sister chromatid cohesion, Negative regulation of cell cycle process, and Epigenetic regulation of gene expression. Each is linked with TOPBP1 in more than 19 cancer types. Because this analysis shows association rather than direction, both TOPBP1-to-partner and partner-to-TOPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid cohesion grouped by TOPBP1-low versus TOPBP1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPBP1→partner) and Y-score (partner→TOPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Mitotic sister chromatid cohesion →	+0.129	+0.904	.001	.001	3	20
BONE	Negative regulation of cell cycle process →	+0.085	+1.035	.005	.002	3	20
LUNG_NSCLC_LUSC	Epigenetic regulation of gene expression →	+0.065	+1.017	<.001	.001	3	20
KIDNEY	DNA-templated DNA replication maintenance of fidelity →	+0.099	+0.736	<.001	<.001	3	20
OESOPHAGUS	Positive regulation of cell cycle →	+0.073	+0.755	<.001	<.001	3	20
OESOPHAGUS	Regulation of chromosome condensation →	+0.187	+0.774	.001	.002	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,943 associations by consensus.

Mitotic sister chromatid cohesion by TOPBP1 expression — OESOPHAGUS

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