TOPBP1

Across TCGA cell cohorts, TOPBP1 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TOPBP1-associated genes across cancer lineages are FKBP6, WDR87, and OR52B4. Each is linked with TOPBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TOPBP1-to-partner and partner-to-TOPBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FKBP6 grouped by TOPBP1-low versus TOPBP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOPBP1→partner) and Y-score (partner→TOPBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FKBP6 →	+0.189	+3.757	<.001	.009	3	2
LARGE_INTESTINE	WDR87 →	+0.014	+2.675	.001	.003	3	2
KIDNEY	OR52B4 →	+0.026	+4.121	.005	.006	3	1
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR13D1 →	+0.025	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

FKBP6 by TOPBP1 expression — BLOOD_Leukemia

Explore this box plot interactively →