TOPBP1

Across TCGA pan-cancer cohorts, TOPBP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TOPBP1 data layer compared with 30 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TOPBP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TOPBP1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where TOPBP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.296	1.000	.003	17	view →
CCRCC	DFS	Median	IV	0.908	0.131	.006	16	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.689	.014	13	view →
PDAC	DFS	Quartile	II,III,IV	0.246	0.526	.012	4	view →
GBM	OS	Tertile	All	0.788	0.936	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TOPBP1–HNSC (OS)

Open the HNSC breakdown →