translocase of outer mitochondrial membrane 70Genealiases: TOMM70A · Tom70
Q-omics provides the consensus-scored TOMM70 profile across patient tissues and cancer cell-line models. TOMM70 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, TOMM70 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, TOMM70 protein abundance shows 26,713 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight ACC, KIRC, and GBM as cancer lineages where TOMM70 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TOMM70 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TOMM70 survival associations across molecular data types. TOMM70 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (2) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TOMM70 RNA expression–survival associations across cancer types. High TOMM70 expression shows unfavorable associations in ACC, LIHC, KICH, PAAD and UCEC, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for TOMM70 RNA expression.
This table summarizes TOMM70 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for TOMM70. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TOMM70 shows lower tumor expression in THCA and higher tumor expression in KIRC, LUAD, LIHC, LUSC and KIRP. The KIRC box plot shows higher TOMM70 RNA expression in tumor versus normal tissue (log2 FC = +0.770, t-test p < 0.001).
This table shows molecular features associated with TOMM70 in patient tissues and cancer cell lines. In patient samples, TOMM70 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, TOMM70 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Lymphoma.
