TOMM70

Across TCGA pan-cancer cohorts, TOMM70 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TOMM70’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where TOMM70 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TOMM70 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and COAD are the cancer types where TOMM70 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TOMM70 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	+0.897	<.001	9	view →
LUAD	Female	II,III,IV	+0.696	<.001	9	view →
COAD	Male	II,III,IV	+0.255	<.001	9	view →
PDAC	All	III,IV	+0.511	.002	7	view →
CCRCC	All	All	−0.279	<.001	7	view →
OV	All	All	+0.243	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TOMM70–LSCC

Open the LSCC breakdown →