TOMM70

Across TCGA patient cohorts, TOMM70 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TOMM70-associated genes across cancer lineages are eEF2, A-Raf_pS299, and FoxM1. Each is linked with TOMM70 in more than 1 cancer types. Because this analysis shows association rather than direction, both TOMM70-to-partner and partner-to-TOMM70 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TOMM70-low versus TOMM70-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TOMM70→partner) and Y-score (partner→TOMM70) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.364	+1.584	.009	.036	3	1
UCEC	A-Raf_pS299 →	-0.222	-3.906	<.001	<.001	3	1
UCEC	FoxM1 →	+0.280	+1.584	.005	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.147	-1.690	.002	.042	3	1
UCEC	Gab2 →	+0.347	+2.999	.013	.035	3	1
UCEC	GATA6 →	-0.173	-3.444	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eEF2 by TOMM70 expression — UCEC

Explore this box plot interactively →