transmembrane 7 superfamily member 3Genealiases: []
Q-omics provides the consensus-scored TM7SF3 profile across patient tissues and cancer cell-line models. TM7SF3 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, TM7SF3 is differentially expressed in 11, with the highest sampling consensus in KICH. Additionally, TM7SF3 RNA expression shows 20,023 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, KICH, and ACC as cancer lineages where TM7SF3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TM7SF3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TM7SF3 survival associations across molecular data types. TM7SF3 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (5) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TM7SF3 RNA expression–survival associations across cancer types. High TM7SF3 expression shows unfavorable associations in ACC, PAAD, UVM and LGG, but favorable associations in KIRC and LAML. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for TM7SF3 RNA expression.
This table summarizes TM7SF3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 5. The strongest signals are observed in KICH for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for TM7SF3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TM7SF3 shows lower tumor expression in KICH and higher tumor expression in BRCA, LIHC, STAD, COAD and CHOL. The KICH box plot shows higher TM7SF3 RNA expression in normal versus tumor tissue (log2 FC = −2.145, t-test p < 0.001).
This table shows molecular features associated with TM7SF3 in patient tissues and cancer cell lines. In patient samples, TM7SF3 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, TM7SF3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and UPPER_AERODIGESTIVE_TRACT.
