TM7SF3

Across TCGA patient cohorts, TM7SF3 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM7SF3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and GAPDH. Each is linked with TM7SF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM7SF3-to-partner and partner-to-TM7SF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TM7SF3-low versus TM7SF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM7SF3→partner) and Y-score (partner→TM7SF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.193	-2.807	.032	<.001	3	2
UCEC	eIF4E →	+0.150	+1.584	.049	.019	3	2
UCEC	GAPDH →	+0.553	+1.925	.004	.005	3	2
UCEC	Rab25 →	-0.439	-2.906	<.001	.001	3	2
UCEC	C-Raf →	+0.177	+3.000	<.001	<.001	3	2
COAD	HSP70 →	+1.031	+2.820	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

EGFR_pY1068 by TM7SF3 expression — UCEC

Explore this box plot interactively →