TM7SF3

Across TCGA cell cohorts, TM7SF3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TM7SF3-associated genes across cancer lineages are EFCAB9, OR10W1, and CD300H. Each is linked with TM7SF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM7SF3-to-partner and partner-to-TM7SF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EFCAB9 grouped by TM7SF3-low versus TM7SF3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM7SF3→partner) and Y-score (partner→TM7SF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EFCAB9 →	+0.022	+4.736	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.045	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

EFCAB9 by TM7SF3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →