TM7SF3

Across TCGA patient cohorts, TM7SF3 mutation is significantly associated with the RNA expression of many other genes, with 3,322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM7SF3-associated genes across cancer lineages are PSMA4, ITGAE, and C12orf65. Each is linked with TM7SF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TM7SF3-to-partner and partner-to-TM7SF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA4 grouped by TM7SF3-low versus TM7SF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM7SF3→partner) and Y-score (partner→TM7SF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMA4 →	+0.435	+2.424	.001	<.001	3	3
UCEC	ITGAE →	+0.595	+3.523	<.001	<.001	3	3
UCEC	C12orf65 →	+0.279	+2.111	.008	.003	3	3
UCEC	COX15 →	+0.529	+2.392	<.001	<.001	3	2
UCEC	GBP5 →	+0.993	+2.403	<.001	<.001	3	2
UCEC	BUB3 →	+0.580	+2.392	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,322 associations by consensus.

PSMA4 by TM7SF3 expression — UCEC

Explore this box plot interactively →