Q-omics provides the consensus-scored TLR4 profile across patient tissues and cancer cell-line models. TLR4 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, TLR4 is differentially expressed in 15, with the highest sampling consensus in LUAD. Additionally, TLR4 RNA expression shows 21,741 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight UCEC, LUAD, and LSCC as cancer lineages where TLR4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TLR4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TLR4 survival associations across molecular data types. TLR4 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TLR4 RNA expression–survival associations across cancer types. High TLR4 expression shows favorable associations in UCEC, KIRC, SKCM, COAD, ACC and LUAD. The UCEC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify UCEC as the clearest survival context for TLR4 RNA expression.
This table summarizes TLR4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 1. The strongest signals are observed in LUAD for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for TLR4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TLR4 shows lower tumor expression in LUAD, LUSC, BRCA, KICH, LIHC and KIRP. The LUAD box plot shows higher TLR4 RNA expression in normal versus tumor tissue (log2 FC = −1.656, t-test p < 0.001).
This table shows molecular features associated with TLR4 in patient tissues and cancer cell lines. In patient samples, TLR4 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, TLR4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BREAST and BONE.
