TLR4

Across TCGA pan-cancer cohorts, TLR4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TLR4 data layer compared with 12 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TLR4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TLR4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRC show a favorable association.

UCEC, KIRC, and SKCM are the cancer types where TLR4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	III,IV	0.754	0.430	.001	90	view →
KIRC	DFS	Median	All	0.706	0.548	<.001	89	view →
SKCM	OS	Median	All	0.403	0.259	<.001	61	view →
COAD	OS	Tertile	III,IV	0.946	0.645	<.001	54	view →
ACC	DFS	Median	All	0.751	0.351	.001	39	view →
LUAD	DFS	Median	All	0.716	0.615	.004	39	view →
HNSC	DFS	Tertile	III,IV	0.661	0.442	<.001	38	view →
LUSC	OS	Quartile	II,III,IV	0.267	0.486	.011	22	view →
CHOL	DFS	Quartile	All	1.000	0.152	.002	21	view →
GBM	DFS	Tertile	All	0.179	0.448	.001	18	view →
LAML	DFS	Median	All	0.421	0.708	.003	18	view →
READ	DFS	Quartile	IV	0.222	0.815	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TLR4–UCEC (OS)

Open the UCEC breakdown →