TLR4

Across TCGA pan-cancer cohorts, TLR4 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TLR4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TLR4 RNA is repressed in tumor relative to normal tissue. In most cancer types TLR4 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and BRCA are the cancer types where TLR4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TLR4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−1.656	<.001	9	view →
LUSC	Female	II,III,IV	−2.514	<.001	8	view →
BRCA	All	III,IV	−1.268	<.001	6	view →
KICH	All	All	−0.991	<.001	6	view →
LIHC	Male	All	−0.867	<.001	6	view →
KIRP	All	II,III,IV	−0.746	.002	6	view →
UCEC	All	All	−1.323	<.001	4	view →
BLCA	All	All	−0.970	.003	4	view →
KIRC	Male	All	+0.558	<.001	4	view →
THCA	All	All	−0.369	.003	4	view →
PAAD	All	All	−1.407	.035	2	view →
CHOL	All	II,III,IV	−1.279	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TLR4–LUAD

Open the LUAD breakdown →