TLR4

Across TCGA cell cohorts, TLR4 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TLR4-associated genes across cancer lineages are OR4X2, PRR20B, and PRR20A. Each is linked with TLR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLR4-to-partner and partner-to-TLR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by TLR4-low versus TLR4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR4→partner) and Y-score (partner→TLR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.032	+5.954	<.001	<.001	3	2
SOFT_TISSUE	PRR20B →	+0.032	+4.977	<.001	.002	3	1
SOFT_TISSUE	PRR20A →	+0.032	+4.977	<.001	.002	3	1
SOFT_TISSUE	KRTAP2-1 →	+0.160	+4.417	<.001	.004	3	1
SOFT_TISSUE	PRR20D →	+0.032	+4.977	<.001	.002	3	1
SOFT_TISSUE	PRR20C →	+0.056	+4.222	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

OR4X2 by TLR4 expression — SOFT_TISSUE

Explore this box plot interactively →