TLR4

Across TCGA patient cohorts, TLR4 mutation is significantly associated with the RNA expression of many other genes, with 5,713 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR4-associated genes across cancer lineages are GNL3, DOLPP1, and CKS1B. Each is linked with TLR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLR4-to-partner and partner-to-TLR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNL3 grouped by TLR4-low versus TLR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR4→partner) and Y-score (partner→TLR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNL3 →	+0.508	+1.868	<.001	<.001	3	4
UCEC	DOLPP1 →	+0.713	+2.688	<.001	<.001	3	4
UCEC	CKS1B →	+0.581	+2.928	.002	<.001	3	4
UCEC	UBE2T →	+0.642	+1.680	<.001	<.001	3	4
LUSC	UGDH →	+0.521	+1.792	.008	.007	3	4
UCEC	SAPCD2 →	+0.650	+1.890	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,713 associations by consensus.

GNL3 by TLR4 expression — UCEC

Explore this box plot interactively →