TLR4

Across TCGA patient cohorts, TLR4 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLR4-associated genes across cancer lineages are PCNA, 4E-BP1, and MYH11. Each is linked with TLR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLR4-to-partner and partner-to-TLR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TLR4-low versus TLR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR4→partner) and Y-score (partner→TLR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.201	+2.415	.004	.003	3	4
UCEC	4E-BP1 →	+0.305	+3.807	<.001	<.001	3	4
LUAD	MYH11 →	-0.672	-2.222	.008	.008	3	3
BRCA	FASN →	+0.644	+2.459	.048	.021	3	3
BRCA	GAPDH →	+0.867	+3.000	.002	.037	3	3
UCEC	eIF4E →	+0.189	+3.472	.006	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

PCNA by TLR4 expression — UCEC

Explore this box plot interactively →