TLR4

Across TCGA cell cohorts, TLR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,088 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TLR4-associated GO terms across cancer lineages are Positive regulation of matrix metallopeptidase secretion, Detection of fungus, and Positive regulation of chemokine (C-X-C motif) ligand 2 production. Each is linked with TLR4 in more than 19 cancer types. Because this analysis shows association rather than direction, both TLR4-to-partner and partner-to-TLR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of matrix metallopeptidase secretion grouped by TLR4-low versus TLR4-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLR4→partner) and Y-score (partner→TLR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of matrix metallopeptidase secretion →	-0.326	-2.048	<.001	<.001	3	20
CNS	Detection of fungus →	+1.595	+2.792	<.001	<.001	3	15
PANCREAS	Positive regulation of chemokine (C-X-C motif) ligand 2 production →	-0.195	-2.027	<.001	<.001	3	10
BLOOD_Leukemia	Intestinal epithelial structure maintenance →	-0.365	-1.526	<.001	<.001	3	10
LIVER	Detection of lipopolysaccharide →	-0.395	-2.062	<.001	<.001	3	10
BONE	Regulation of plasminogen activation →	+0.252	+1.910	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,088 associations by consensus.

Positive regulation of matrix metallopeptidase secretion by TLR4 expression — BLOOD_Leukemia

Explore this box plot interactively →