TBC1 domain family member 8Genealiases: AD3 · GRAMD8 · HBLP1 · TBC1D8A · VRP
Q-omics provides the consensus-scored TBC1D8 profile across patient tissues and cancer cell-line models. TBC1D8 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, TBC1D8 is differentially expressed in 8, with the highest sampling consensus in KICH. Additionally, TBC1D8 RNA expression shows 20,024 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight SKCM, KICH, and THYM as cancer lineages where TBC1D8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TBC1D8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TBC1D8 survival associations across molecular data types. TBC1D8 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (9) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TBC1D8 RNA expression–survival associations across cancer types. High TBC1D8 expression shows unfavorable associations in COAD, KIRP and UVM, but favorable associations in SKCM, HNSC and BRCA. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for TBC1D8 RNA expression.
This table summarizes TBC1D8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 5. The strongest signals are observed in KICH for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for TBC1D8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TBC1D8 shows lower tumor expression in KICH and THCA and higher tumor expression in COAD, LIHC, STAD and READ. The KICH box plot shows higher TBC1D8 RNA expression in normal versus tumor tissue (log2 FC = −2.234, t-test p < 0.001).
This table shows molecular features associated with TBC1D8 in patient tissues and cancer cell lines. In patient samples, TBC1D8 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, TBC1D8 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SOFT_TISSUE.
