Across TCGA pan-cancer cohorts, TBC1D8 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TBC1D8 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TBC1D8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TBC1D8 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where TBC1D8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.897	0.525	.005	19	view →
PDAC	DFS	Tertile	II,III,IV	0.585	0.831	.006	10	view →
HNSC	OS	Median	III,IV	1.000	0.449	.023	6	view →
LUAD	DFS	Tertile	III,IV	0.340	0.846	.047	2	view →
LSCC	OS	Median	All	1.000	0.813	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TBC1D8 tumor-vs-normal RNA expression · all TBC1D8 data types