Across TCGA patient cohorts, TBC1D8 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D8-associated genes across cancer lineages are mTOR, p90 RSK, and Caveolin-1. Each is linked with TBC1D8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D8-to-partner and partner-to-TBC1D8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D8→partner) and Y-score (partner→TBC1D8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.097	-1.584	.039	.034	3	3
STAD	p90 RSK →	+0.358	+3.000	.006	.036	3	2
STAD	Caveolin-1 →	-1.110	-3.000	.004	.036	3	2
UCEC	ERK2 →	+0.155	+2.415	.005	.002	3	2
UCEC	Rad50 →	-0.164	-1.295	.019	.010	3	2
UCEC	Shc_pY317 →	-0.120	-1.502	.006	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

TBC1D8 survival (RNA) · tumor vs normal (RNA) · all TBC1D8 data types