Q-omics provides the consensus-scored STXBP3 profile across patient tissues and cancer cell-line models. STXBP3 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, STXBP3 is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, STXBP3 RNA expression shows 20,315 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, THCA, and ACC as cancer lineages where STXBP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for STXBP3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes STXBP3 survival associations across molecular data types. STXBP3 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (3) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible STXBP3 RNA expression–survival associations across cancer types. High STXBP3 expression shows unfavorable associations in SCLC, LIHC, LGG, KICH and KIRP, but favorable associations in KIRC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for STXBP3 RNA expression.
This table summarizes STXBP3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 5. The strongest signals are observed in THCA for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for STXBP3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. STXBP3 shows lower tumor expression in THCA, UCEC, KIRC and KICH and higher tumor expression in LIHC and STAD. The THCA box plot shows higher STXBP3 RNA expression in normal versus tumor tissue (log2 FC = −0.719, t-test p < 0.001).
This table shows molecular features associated with STXBP3 in patient tissues and cancer cell lines. In patient samples, STXBP3 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, STXBP3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BLOOD_Lymphoma.
