STXBP3

Across TCGA pan-cancer cohorts, STXBP3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated STXBP3 data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher STXBP3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated STXBP3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LIHC, UCEC, and COAD are the cancer types where STXBP3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	II,III,IV	0.080	0.431	<.001	39	view →
UCEC	DFS	Median	II,III,IV	0.941	0.712	.019	10	view →
COAD	DFS	Median	All	0.222	0.699	.004	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

STXBP3–LIHC (DFS)

Open the LIHC breakdown →