STXBP3

Across TCGA patient cohorts, STXBP3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP3-associated genes across cancer lineages are Ku80, PCNA, and PEA-15. Each is linked with STXBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP3-to-partner and partner-to-STXBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by STXBP3-low versus STXBP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP3→partner) and Y-score (partner→STXBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.255	+1.778	.004	.008	3	2
UCEC	PCNA →	+0.254	+2.169	.001	.003	3	2
UCEC	PEA-15 →	+0.139	+1.765	.049	.014	3	2
UCEC	EGFR_pY1068 →	-0.248	-2.169	.008	.003	3	1
UCEC	EGFR →	-0.169	-1.415	.004	.046	3	1
UCEC	eIF4G →	+0.299	+3.321	.010	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Ku80 by STXBP3 expression — UCEC

Explore this box plot interactively →