STXBP3

Across TCGA cell cohorts, STXBP3 mutation is significantly associated with the mutation status of many other genes, with 1,468 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STXBP3-associated genes across cancer lineages are SALL1, SLCO1B3, and RALBP1. Each is linked with STXBP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both STXBP3-to-partner and partner-to-STXBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SALL1 grouped by STXBP3-low versus STXBP3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP3→partner) and Y-score (partner→STXBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SALL1 →	+4.459	+5.277	.005	.005	1	3
BLOOD_Leukemia	SLCO1B3 →	+5.145	+5.145	<.001	<.001	1	3
BLOOD_Leukemia	RALBP1 →	+3.823	+4.430	.001	.001	1	3
CNS	FAM13B →	+5.044	+5.614	.003	.003	1	3
CNS	CDC5L →	+5.044	+5.614	.003	.003	1	3
LARGE_INTESTINE	WNT5A →	+2.459	+3.321	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,468 associations by consensus.

SALL1 by STXBP3 expression — CNS

Explore this box plot interactively →