STXBP3

Across TCGA pan-cancer cohorts, STXBP3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated STXBP3 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher STXBP3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated STXBP3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where STXBP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.499	0.268	<.001	51	view →
HNSC	OS	Tertile	IV	0.837	0.591	.048	1	view →
LSCC	DFS	Median	All	0.929	0.615	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

STXBP3–PDAC (OS)

Open the PDAC breakdown →