STXBP3

Across TCGA cell cohorts, STXBP3 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STXBP3-associated genes across cancer lineages are PPP1R2C, CST8, and TPD52L3. Each is linked with STXBP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STXBP3-to-partner and partner-to-STXBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP1R2C grouped by STXBP3-low versus STXBP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP3→partner) and Y-score (partner→STXBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PPP1R2C →	+0.307	+5.539	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.062	+5.969	<.001	.001	3	1
BLOOD_Leukemia	TPD52L3 →	+0.012	+5.539	<.001	.003	3	1
BLOOD_Leukemia	OR6C70 →	+0.021	+4.922	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.977	<.001	.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.020	+3.196	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PPP1R2C by STXBP3 expression — BLOOD_Leukemia

Explore this box plot interactively →