STXBP3

Across TCGA patient cohorts, STXBP3 mutation is significantly associated with the RNA expression of many other genes, with 1,921 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP3-associated genes across cancer lineages are TRAJ58, RNU7-179P, and RNA5SP137. Each is linked with STXBP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both STXBP3-to-partner and partner-to-STXBP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ58 grouped by STXBP3-low versus STXBP3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP3→partner) and Y-score (partner→STXBP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ58 →	+0.647	+3.686	<.001	.005	3	3
LIHC	RNU7-179P →	+0.344	+4.564	<.001	.006	3	2
LIHC	RNA5SP137 →	+0.186	+4.423	<.001	.007	3	2
BRCA	RNU6-1198P →	+0.559	+5.270	.004	.001	3	2
BRCA	BPTFP1 →	+0.155	+4.766	<.001	.003	3	2
LIHC	MTCO2P31 →	+0.059	+4.293	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,921 associations by consensus.

TRAJ58 by STXBP3 expression — COAD

Explore this box plot interactively →