Q-omics provides the consensus-scored STRAP profile across patient tissues and cancer cell-line models. STRAP expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in MESO. Among the 18 cancer types available for tumor–normal comparison, STRAP is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, STRAP protein abundance shows 21,263 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight MESO, HNSC, and PDAC as cancer lineages where STRAP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for STRAP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes STRAP survival associations across molecular data types. STRAP RNA expression shows survival associations in the most cancer types (23), followed by mutation status (5) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible STRAP RNA expression–survival associations across cancer types. High STRAP expression shows unfavorable associations in MESO, ACC, LUAD, HNSC, CESC and LIHC. The MESO Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify MESO as the clearest survival context for STRAP RNA expression.
This table summarizes STRAP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for STRAP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. STRAP shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, COAD, STAD and LUSC. The HNSC box plot shows higher STRAP RNA expression in tumor versus normal tissue (log2 FC = +0.882, t-test p < 0.001).
This table shows molecular features associated with STRAP in patient tissues and cancer cell lines. In patient samples, STRAP shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, STRAP RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and BLOOD_Lymphoma.
