STRAP

Across TCGA patient cohorts, STRAP mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STRAP-associated genes across cancer lineages are PEA-15_pS116, Rab25, and ATM. Each is linked with STRAP in more than 1 cancer types. Because this analysis shows association rather than direction, both STRAP-to-partner and partner-to-STRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by STRAP-low versus STRAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STRAP→partner) and Y-score (partner→STRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.359	+2.459	.034	.020	3	1
UCEC	Rab25 →	-0.359	-3.000	.025	.036	3	1
UCEC	ATM →	-0.475	-2.459	.030	.020	3	1
UCEC	Caspase-8 →	-0.274	-3.321	.023	.010	3	1
UCEC	Ku80 →	+0.226	+2.472	.048	.011	2	1
UCEC	ERK2 →	+0.258	+2.459	.005	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PEA-15_pS116 by STRAP expression — UCEC

Explore this box plot interactively →