STRAP

Across TCGA pan-cancer cohorts, STRAP RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated STRAP data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher STRAP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated STRAP expression acts as an unfavorable survival marker, although some lineages such as READ and OV show a favorable association.

MESO, ACC, and HNSC are the cancer types where STRAP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.410	0.674	<.001	105	view →
ACC	DFS	Median	All	0.229	0.663	<.001	89	view →
HNSC	OS	Tertile	All	0.477	0.789	<.001	70	view →
LUAD	DFS	Tertile	All	0.714	0.837	<.001	70	view →
CESC	DFS	Median	III,IV	0.566	0.892	.001	52	view →
LIHC	OS	Quartile	All	0.626	0.820	<.001	46	view →
UVM	DFS	Median	III,IV	0.335	0.732	<.001	33	view →
BLCA	OS	Quartile	II,III,IV	0.505	0.667	.007	30	view →
READ	OS	Tertile	II,III,IV	0.974	0.399	.001	22	view →
PAAD	OS	Quartile	II,III,IV	0.442	0.806	.001	19	view →
SARC	OS	Quartile	All	0.378	0.743	.002	17	view →
UCEC	DFS	Tertile	All	0.785	0.889	.004	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

STRAP–MESO (OS)

Open the MESO breakdown →