spindle and kinetochore associated complex subunit 3Genealiases: C13orf3 · RAMA1
Q-omics provides the consensus-scored SKA3 profile across patient tissues and cancer cell-line models. SKA3 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, SKA3 is differentially expressed in 16, with the highest sampling consensus in HNSC. Additionally, SKA3 RNA expression shows 26,331 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, HNSC, and LSCC as cancer lineages where SKA3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SKA3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SKA3 survival associations across molecular data types. SKA3 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (5) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SKA3 RNA expression–survival associations across cancer types. High SKA3 expression shows unfavorable associations in ACC, MESO, KIRP, LIHC, LUAD and KICH. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for SKA3 RNA expression.
This table summarizes SKA3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for SKA3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SKA3 shows higher tumor expression in HNSC, KIRC, BLCA, LUAD, COAD and KIRP. The HNSC box plot shows higher SKA3 RNA expression in tumor versus normal tissue (log2 FC = +1.577, t-test p < 0.001).
This table shows molecular features associated with SKA3 in patient tissues and cancer cell lines. In patient samples, SKA3 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SKA3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
