SKA3

Across TCGA cell cohorts, SKA3 mutation is significantly associated with the mutation status of many other genes, with 3,842 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SKA3-associated genes across cancer lineages are IMPG2, IRS1, and SPHK1. Each is linked with SKA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SKA3-to-partner and partner-to-SKA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMPG2 grouped by SKA3-low versus SKA3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA3→partner) and Y-score (partner→SKA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IMPG2 →	+4.297	+4.857	.009	.009	1	3
SKIN	IRS1 →	+3.638	+4.117	.002	.002	1	3
LARGE_INTESTINE	SPHK1 →	+5.459	+4.744	<.001	<.001	1	3
BREAST	NUP107 →	+4.297	+4.857	.009	.009	1	3
LARGE_INTESTINE	PAIP1 →	+3.874	+4.215	<.001	<.001	1	3
LARGE_INTESTINE	OR10K1 →	+3.874	+4.215	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,842 associations by consensus.

IMPG2 by SKA3 expression — BREAST

Explore this box plot interactively →