SKA3

Across TCGA cell cohorts, SKA3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SKA3-associated genes across cancer lineages are KRTAP10-10, GPR26, and PRY. Each is linked with SKA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKA3-to-partner and partner-to-SKA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-10 grouped by SKA3-low versus SKA3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA3→partner) and Y-score (partner→SKA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-10 →	+0.068	+3.347	<.001	.005	3	2
LUNG_NSCLC_LUAD	GPR26 →	+0.016	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRY →	+0.016	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PRY2 →	+0.016	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPRR2B →	+0.047	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	POTEB2 →	+0.026	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

KRTAP10-10 by SKA3 expression — LARGE_INTESTINE

Explore this box plot interactively →