SKA3

Across TCGA patient cohorts, SKA3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,989 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SKA3-associated genes across cancer lineages are RFC3, GINS4, and CIP2A. Each is linked with SKA3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SKA3-to-partner and partner-to-SKA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SKA3 versus RFC3 in GBM, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA3→partner) and Y-score (partner→SKA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC3 →	+0.897	+0.632	<.001	<.001	3	7
LUAD	GINS4 →	+1.082	+0.884	.002	.004	3	7
UCEC	CIP2A →	+0.935	+0.396	<.001	.003	3	7
GBM	CENPI →	+1.079	+0.678	<.001	<.001	3	6
OV	OIP5 →	+0.802	+0.906	.003	<.001	3	6
LUAD	RAD51AP1 →	+1.172	+0.762	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,989 associations by consensus.

SKA3 vs RFC3 — GBM

Explore this scatter interactively →