SKA3

Across TCGA patient cohorts, SKA3 mutation is significantly associated with the RNA expression of many other genes, with 1,553 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SKA3-associated genes across cancer lineages are TRAJ31, LINC01069, and ZNF519P4. Each is linked with SKA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SKA3-to-partner and partner-to-SKA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ31 grouped by SKA3-low versus SKA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SKA3→partner) and Y-score (partner→SKA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ31 →	+0.885	+1.939	<.001	.002	3	2
LUSC	LINC01069 →	+0.132	+5.882	.001	.002	3	2
LUSC	ZNF519P4 →	+0.563	+5.404	<.001	.005	3	2
SKCM	PSMB7P1 →	+0.045	+4.469	<.001	.006	3	2
COAD	RNU6-1289P →	+1.052	+4.942	<.001	<.001	3	2
COAD	MIR4418 →	+0.450	+4.308	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,553 associations by consensus.

TRAJ31 by SKA3 expression — UCEC

Explore this box plot interactively →