secreted frizzled related protein 1Genealiases: FRP · FRP-1 · FRP1 · FrzA · SARP2
Q-omics provides the consensus-scored SFRP1 profile across patient tissues and cancer cell-line models. SFRP1 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, SFRP1 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, SFRP1 protein abundance shows 22,969 significant protein co-abundance associations, with the highest sampling consensus in UCEC. Together, these results highlight HNSC, KIRC, and UCEC as cancer lineages where SFRP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SFRP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SFRP1 survival associations across molecular data types. SFRP1 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (3) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SFRP1 RNA expression–survival associations across cancer types. High SFRP1 expression shows unfavorable associations in ACC and KIRP, but favorable associations in HNSC, UCS, SKCM and BRCA. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for SFRP1 RNA expression.
This table summarizes SFRP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 9. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SFRP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SFRP1 shows lower tumor expression in KIRC, COAD, KICH, KIRP, BLCA and THCA. The KIRC box plot shows higher SFRP1 RNA expression in normal versus tumor tissue (log2 FC = −6.296, t-test p < 0.001).
This table shows molecular features associated with SFRP1 in patient tissues and cancer cell lines. In patient samples, SFRP1 shows the broadest associations at the RNA and protein expression levels, with UCEC recurring as the lineage with the largest associated feature set. In cancer cell lines, SFRP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and BREAST.
