SFRP1

Across TCGA cell cohorts, SFRP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,050 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SFRP1-associated GO terms across cancer lineages are Regulation of midbrain dopaminergic neuron differentiation, Protein folding, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with SFRP1 in more than 8 cancer types. Because this analysis shows association rather than direction, both SFRP1-to-partner and partner-to-SFRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of midbrain dopaminergic neuron differentiation grouped by SFRP1-low versus SFRP1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP1→partner) and Y-score (partner→SFRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of midbrain dopaminergic neuron differentiation →	+1.624	+2.558	<.001	<.001	3	8
OESOPHAGUS	Protein folding →	+0.066	+1.902	.003	.002	3	8
OESOPHAGUS	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.135	+2.060	.001	.003	2	9
BREAST	MHC class I protein complex assembly →	+0.172	+3.186	<.001	<.001	3	7
BREAST	Peptide antigen assembly with MHC class I protein complex →	+0.172	+3.186	<.001	<.001	3	7
BREAST	Regulation of inflammatory response to antigenic stimulus →	+0.091	+2.471	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,050 associations by consensus.

Regulation of midbrain dopaminergic neuron differentiation by SFRP1 expression — LUNG_SCLC

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