SFRP1

Across TCGA patient cohorts, SFRP1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFRP1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, 14-3-3_beta, and eEF2. Each is linked with SFRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFRP1-to-partner and partner-to-SFRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SFRP1-low versus SFRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP1→partner) and Y-score (partner→SFRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.466	-1.687	.014	.044	3	2
UCEC	14-3-3_beta →	-0.113	-3.295	.008	.009	3	1
UCEC	eEF2 →	+0.326	+2.999	.031	.035	3	1
UCEC	EGFR_pY1068 →	-0.289	-2.906	.006	.001	3	1
UCEC	FOXO3a_pS318_S321 →	-0.106	-2.449	.046	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.205	-2.321	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

p38-MAPK_pT180_Y182 by SFRP1 expression — UCEC

Explore this box plot interactively →