SFRP1

Across TCGA patient cohorts, SFRP1 mutation is significantly associated with the RNA expression of many other genes, with 1,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SFRP1-associated genes across cancer lineages are OR4N2, ARGFX, and OR9Q2. Each is linked with SFRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SFRP1-to-partner and partner-to-SFRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4N2 grouped by SFRP1-low versus SFRP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SFRP1→partner) and Y-score (partner→SFRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR4N2 →	+0.073	+3.668	<.001	.002	3	2
SKCM	ARGFX →	+0.044	+3.393	<.001	.003	3	2
SKCM	OR9Q2 →	+0.020	+4.671	<.001	.004	3	2
SKCM	RNA5SP248 →	+0.253	+3.045	.001	.008	3	2
SKCM	MIR521-1 →	+0.263	+5.163	<.001	.002	3	2
SKCM	MIR519A1 →	+0.224	+4.302	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,067 associations by consensus.

OR4N2 by SFRP1 expression — SKCM

Explore this box plot interactively →