SFRP1

Across TCGA pan-cancer cohorts, SFRP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SFRP1 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SFRP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SFRP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, UCEC, and COAD are the cancer types where SFRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.831	0.578	<.001	43	view →
UCEC	OS	Tertile	III,IV	0.403	1.000	.032	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LSCC	OS	Median	II,III,IV	0.897	1.000	.012	5	view →
CCRCC	DFS	Quartile	III,IV	0.233	0.887	.038	4	view →
LUAD	OS	Quartile	III,IV	0.197	0.812	.029	3	view →
GBM	DFS	Median	All	0.284	0.428	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SFRP1–PDAC (DFS)

Open the PDAC breakdown →