serpin family A member 5Genealiases: PAI-3 · PAI3 · PCI · PCI-B · PLANH3 · PROCI
Q-omics provides the consensus-scored SERPINA5 profile across patient tissues and cancer cell-line models. SERPINA5 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SERPINA5 is differentially expressed in 15, with the highest sampling consensus in KIRC. Additionally, SERPINA5 protein abundance shows 27,570 significant protein co-abundance associations, with the highest sampling consensus in LUAD. Together, these results highlight KIRC, and LUAD as cancer lineages where SERPINA5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SERPINA5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SERPINA5 survival associations across molecular data types. SERPINA5 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SERPINA5 RNA expression–survival associations across cancer types. High SERPINA5 expression shows unfavorable associations in KIRC, STAD, CESC, LGG and KIRP, but favorable associations in BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SERPINA5 RNA expression.
This table summarizes SERPINA5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SERPINA5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SERPINA5 shows lower tumor expression in KIRC, KIRP, THCA, COAD, BLCA and HNSC. The KIRC box plot shows higher SERPINA5 RNA expression in normal versus tumor tissue (log2 FC = −5.973, t-test p < 0.001).
This table shows molecular features associated with SERPINA5 in patient tissues and cancer cell lines. In patient samples, SERPINA5 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set. In cancer cell lines, SERPINA5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in BONE and BLOOD_Leukemia.
