Across TCGA cell cohorts, SERPINA5 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SERPINA5-associated genes across cancer lineages are CA5A, GRM6, and TAS2R9. Each is linked with SERPINA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERPINA5-to-partner and partner-to-SERPINA5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINA5→partner) and Y-score (partner→SERPINA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	GRM6 →	+0.225	+2.825	<.001	.007	3	1
LUNG_NSCLC_LUAD	TAS2R9 →	+0.041	+2.958	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR8B12 →	+0.054	+3.149	<.001	.002	3	1
LUNG_NSCLC_LUAD	NXNL1 →	+0.024	+3.491	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.008	+3.681	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

SERPINA5 survival (RNA) · tumor vs normal (RNA) · all SERPINA5 data types